General and Efficient Copper-Catalyzed Amidation of Saturated C−H Bonds Using N-Halosuccinimides as the Oxidants

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• 作者：Xiaowei Liu ; Yongming Zhang ; Long Wang ; Hua Fu ; Yuyang Jiang ; Yufen Zhao
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：August 15, 2008
• 年：2008
• 卷：73
• 期：16
• 页码：6207-6212
• 全文大小：259K
• 年卷期：v.73,no.16(August 15, 2008)
• ISSN：1520-6904

文摘

We have developed a general and efficient method for copper-catalyzed amidation of saturated C−H bonds under mild conditions, and the used substrates include benzylic reagents, the N,N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C−H activation.