Filicinic Acid Based Meroterpenoids with Anti-Epstein–Barr Virus Activities from Hypericum japonicum

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• 作者：Linzhen Hu ; Yu Zhang ; Hucheng Zhu ; Junjun Liu ; Hua Li ; Xiao-Nian Li ; Weiguang Sun ; Junfen Zeng ; Yongbo Xue ; Yonghui Zhang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2272-2275
• 全文大小：328K
• 年卷期：0
• ISSN：1523-7052

文摘

Seven filicinic acid–based meroterpenoids (1–7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from Hypericum japonicum. All of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein–Barr virus, with EC₅₀ values of 0.57 and 0.49 μM, respectively. Furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2GV9 predicted by the molecular docking.