Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived Fungus Chaetomium globosum

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• 作者：Chunmei Chen ; Hucheng Zhu ; Xiao-Nian Li ; Jing Yang ; Jianping Wang ; Gentao Li ; Yan Li ; Qingyi Tong ; Guangmin Yao ; Zengwei Luo ; Yongbo Xue ; Yonghui Zhang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：644-647
• 全文大小：310K
• ISSN：1523-7052

文摘

Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold.