Streptothricin Derivatives from Streptomyces sp. I08A 1776

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• 作者：Maoluo Gan ; Xudong Zheng ; Lishe Gan ; Yan Guan ; Xueqin Hao ; Yishuang Liu ; Shuyi Si ; Yuqin Zhang ; Liyan Yu ; Chunling Xiao
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1142-1147
• 全文大小：805K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Five new streptothricin derivatives with a carbamoyl group substituted at C-12 (1鈥?b>5) and three known analogues have been isolated from the culture broth of Streptomyces sp. I08A 1776 by ion exchange and hydrophilic interaction chromatographic techniques. Their structures were determined by spectroscopic and chemical methods. Compound 3 was a streptothricin derivative possessing a cis-streptolidine moiety. Its absolute configuration was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compound 5 and streptothricin E (6) displayed antibacterial and antifungal activity with MIC values in the range 1鈥?4 渭g/mL.