Synthesis of Benzimidazolones via One-Pot Reaction of Hydroxylamines, Aldehydes, and Trimethylsilyl Cyanide Promoted by Diacetoxyiodobenzene

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• 作者：Huaiyuan Zhang ; Danfeng Huang ; Ke-Hu Wang ; Jun Li ; Yingpeng SuYulai Hu
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：82
• 期：3
• 页码：1600-1609
• 全文大小：640K
• ISSN：1520-6904

文摘

A novel and efficient PhI(OAc)₂-promoted one-pot reaction of aromatic hydroxylamines, aldehydes, and TMSCN in the presence of BF₃·Et₂O is described. A wide variety of N-substituted benzimidazolones are obtained with satisfactory yields under mild reaction conditions. The method was proven to be efficient for the synthesis of benzimidazolone derivatives from readily available starting materials.