Selective Access to Trisubstituted Macrocyclic E- and Z-Alkenes from the Ring-Closing Metathesis of Vinylsiloxanes

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• 作者：Yikai Wang ; Miguel Jimenez ; Patrick Sheehan ; Cheng Zhong ; Alvin W. Hung ; Chun Pong Tam ; Damian W. Young
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：15
• 期：6
• 页码：1218-1221
• 全文大小：256K
• 年卷期：v.15,no.6(March 15, 2013)
• ISSN：1523-7052

文摘

Macrocyclic (E)-alkenylsiloxanes, obtained from E-selective ring-closing metathesis reactions, can be converted to the corresponding (Z)-alkenyl bromides and (E)-alkenyl iodides allowing access to both E- and Z-trisubstituted macrocyclic alkenes. The reaction conditions and substrate scope of these stereoselective transformations are explored.