Synthesis of Quaternary 3,3-Disubstituted 2-Oxindoles from 2-Substituted Indole Using Selectfluor

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• 作者：Xiaojian Jiang ; Junjie Yang ; Feng Zhang ; Pei Yu ; Peng Yi ; Yewei Sun ; Yuqiang Wang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：18
• 期：13
• 页码：3154-3157
• 全文大小：402K
• 年卷期：0
• ISSN：1523-7052

文摘

A facile method to construct quaternary 3,3-disubstituted 2-oxindole from 2-substituted indole without a catalyst in mild conditions is developed. A mechanistic study suggests that an iminium-intermediate-triggered 1,2-rearrangement is involved, and a trace amount of water is required for subsequent oxidation.