Mixed Ligand CuIIN2O2 Complexes: Biomimetic Synthesis, Activities in Vitro and Biological Models, Theoretical Calculations
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- 作者：Chen Li ; Bing Yin ; Yifan Kang ; Ping Liu ; Liang Chen ; Yaoyu Wang ; Jianli Li
- 刊名：Inorganic Chemistry
- 出版年：2014
- 出版时间：December 15, 2014
- 年：2014
- 卷：53
- 期：24
- 页码：13019-13030
- 全文大小：846K
- ISSN：1520-510X
文摘
Three new mixed ligand CuIIN2O2 complexes, namely, [CuII(2-A-6-MBT)2(m-NB)2] (1), [CuII(2-ABT)2(m-NB)2] (2), and [CuII(2-ABT)2(o-NB)2] (3), (2-A-6-MBT = 2-amino-6-methoxybenzothiazole, m-NB = m-nitrobenzoate, 2-ABT = 2-aminobenzothiazole, and o-NB = o-nitrobenzoate), have been prepared by the biomimetic synthesis strategy, and their structures were determined by X-ray crystallography studies and spectral methods. These complexes exhibited the effective superoxide dismutase (SOD) activity and catecholase activity. On the basis of the experimental data and computational studies, the structure鈥揳ctivity relationship for these complexes was investigated. The results reveal that electron-accepting abilities of these complexes and coordination geometries have significant effects on the SOD activity and catecholase activity. Then, we found that 1 and 2 exerted potent intracellular antioxidant capacity in the model of H2O2-induced oxidative stress based on HeLa cervical cancer cells, which were screened out by the cytotoxicity assays of different kinds of cells. Furthermore, 1鈥?b>3 showed the favorable biocompatibility in two different biological models: Saccharomyces cerevisiae and human vascular endothelial cells. These biological experimental data are indicative of the promising application potential of these complexes in biology and pharmacology.