Cytotoxic and Antimycobacterial Prenylated Flavonoids from the Roots of Eriosema chinense

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• 作者：Somyote Sutthivaiyakit ; Oracha Thongnak ; Thitima Lhinhatrakool ; Orapan Yodchun ; Ratree Srimark ; Prisana Dowtaisong ; Mayuree Chuankamnerdkarn
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：June 26, 2009
• 年：2009
• 卷：72
• 期：6
• 页码：1092-1096
• 全文大小：106K
• 年卷期：v.72,no.6(June 26, 2009)
• ISSN：1520-6025

文摘

Eight new prenylated flavonoids, khonklonginols A−H (1−8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1−8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.