Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons

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• 作者：Yan Lyu ; Chen Xie ; Svetlana A. Chechetka ; Eijiro Miyako ; Kanyi Pu
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：July 27, 2016
• 年：2016
• 卷：138
• 期：29
• 页码：9049-9052
• 全文大小：313K
• 年卷期：0
• ISSN：1520-5126

文摘

Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potential alternative approach to optogenetics using semiconducting polymer nanobioconjugates (SPNs_bc) as the photothermal nanomodulator to control the thermosensitive ion channels in neurons. SPNs_bc are designed to efficiently absorb the NIR light at 808 nm and have a photothermal conversion efficiency higher than that of gold nanorods. By virtue of the fast heating capability in conjunction with the precise targeting to the thermosensitive ion channel, SPNs_bc can specifically and rapidly activate the intracellular Ca²⁺ influx of neuronal cells in a reversible and safe manner. Our study provides an organic nanoparticle based strategy that eliminates the need for genetic transfection to remotely regulate cellular machinery.