Variation in Cytostatic Constituents of a Sponge-Derived Gymnascella dankaliensis by Manipulating the Carbon Source
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- 作者：Taro Amagata ; Makoto Tanaka ; Takeshi Yamada ; Mitsunobu Doi ; Katsuhiko Minoura ; Hirofumi Ohishi ; Takao Yamori ; Atsushi Numata
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：70
- 期：11
- 页码：1731 - 1740
- 全文大小：199K
- 年卷期：v.70,no.11(November 2007)
- ISSN：1520-6025
文摘
The Halichondria sponge-derived fungus, Gymnacella dankaliensis, was cultured in two different media conditions. A modified malt extract medium containing soluble starch instead of glucose resulted in two extremely unusual steroids, dankasterones A (2) and B (3), while four additional unusual steroids, gymnasterones A (4), B (5), C (6), and D (7), were isolated from the original malt extract medium. Their stereostructures have been established on the basis of spectroscopic analyses along with X-ray crystal structure analyses, modified Mosher's method, CD exciton method, and a chemical transformation. All the steroids except for 4 exhibited significant growth inhibition against the murine P388 cancer cell line. Dankasterone A (2) also exhibited potent growth inhibition against human cancer cell lines.