A Series of Cinchona-Derived N-Oxide Phase-Transfer Catalysts: Application to the Photo-Organocatalytic Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds
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- 作者：Yakun Wang ; Hang Yin ; Xiaofei Tang ; Yufeng Wu ; Qingwei Meng ; Zhanxian Gao
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：August 19, 2016
- 年：2016
- 卷：81
- 期：16
- 页码：7042-7050
- 全文大小：474K
- 年卷期：0
- ISSN：1520-6904
文摘
A series of cinchona-derived N-oxide asymmetric phase-transfer catalysts were synthesized and applied in the enantioselective photo-organocatalytic α-hydroxylation of β-keto esters and β-keto amides (23 examples) using molecular oxygen in excellent yields (up to 98%) and high enantioselectivities (up to 83% ee). These new catalysts could be recycled and reused six times for such a reaction with almost the original reactivity and enantioselectivity.