Iridium-Catalyzed Direct C鈥揌 Sulfamidation of Aryl Nitrones with Sulfonyl Azides at Room Temperature

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• 作者：Chao Pi ; Xiuling Cui ; Yangjie Wu
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：80
• 期：15
• 页码：7333-7339
• 全文大小：440K
• ISSN：1520-6904

文摘

Ir(III)-catalyzed direct C鈥揌 sulfamidation of aryl nitrones has been developed to synthesize various sulfamidated nitrones in moderate to excellent yields with excellent regioselectivity and broad functional group tolerance. This transformation could proceed smoothly at room temperature with low catalyst loading in the absence of external oxidants, acids, or bases. Molecular nitrogen was released as the sole byproduct, thus providing an environmentally benign sulfamidation process. And this protocol could efficiently apply to synthesize the substituted benzisoxazoline via one-step transformation from the product.