文摘
We show here that a series of triazolyl glycolipid derivatives modularly synthesized by a 鈥渃lick鈥?reaction have the ability to increase the susceptibility of a drug-resistant bacterium to 尾-lactam antibiotics. We determine that the glycolipids can suppress the minimal inhibitory concentration of a number of ineffective 尾-lactams, upward of 256-fold, for methicillin-resistant Staphylococuss aureus (MRSA). The mechanism of action has been preliminarily probed and discussed.