Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

详细信息    查看全文

• 作者：Sreekanth Kokkonda ; Xiaoyi Deng ; Karen L. White ; Jose M. Coteron ; Maria Marco ; Laura de las Heras ; John White ; Farah El Mazouni ; Diana R. Tomchick ; Krishne Manjalanagara ; Kakali Rani Rudra ; Gong Chen ; Julia Morizzi ; Eileen Ryan ; Werner Kaminsky ; Didier Leroy ; María Santos Martínez-Martínez ; Maria Belen Jimenez-Diaz ; Santiago Ferrer Bazaga ; Iñigo Angulo-Barturen ; David Waterson ; Jeremy N. Burrows ; Dave Matthews ; Susan A. Charman ; Margaret A. Phillips ; Pradipsinh K. Rathod
• 刊名：Journal of Medicinal Chemistry
• 出版年：2016
• 出版时间：June 9, 2016
• 年：2016
• 卷：59
• 期：11
• 页码：5416-5431
• 全文大小：566K
• 年卷期：0
• ISSN：1520-4804

文摘

Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new malaria drug target, and a triazolopyrimidine-based DHODH inhibitor 1 (DSM265) is in clinical development. We sought to identify compounds with higher potency against Plasmodium DHODH while showing greater selectivity toward animal DHODHs. Herein we describe a series of novel triazolopyrimidines wherein the p-SF₅-aniline was replaced with substituted 1,2,3,4-tetrahydro-2-naphthyl or 2-indanyl amines. These compounds showed strong species selectivity, and several highly potent tetrahydro-2-naphthyl derivatives were identified. Compounds with halogen substitutions displayed sustained plasma levels after oral dosing in rodents leading to efficacy in the P. falciparum SCID mouse malaria model. These data suggest that tetrahydro-2-naphthyl derivatives have the potential to be efficacious for the treatment of malaria, but due to higher metabolic clearance than 1, they most likely would need to be part of a multidose regimen.