Preparation and Characterization of a Novel Electrospun Spider Silk Fibroin/Poly(d,l-lactide) Composite Fiber

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• 作者：Shaobing Zhou ; Hongsen Peng ; Xiongjun Yu ; Xiaotong Zheng ; Wenguo Cui ; Zairong Zhang ; Xiaohong Li ; Jianxin Wang ; Jie Weng ; Wenxiang Jia ; Fei Li
• 刊名：Journal of Physical Chemistry B
• 出版年：2008
• 出版时间：September 11, 2008
• 年：2008
• 卷：112
• 期：36
• 页码：11209-11216
• 全文大小：481K
• 年卷期：v.112,no.36(September 11, 2008)
• ISSN：1520-5207

文摘

In the paper, we successfully prepared spider silk fibroins (Ss)/poly(d,l-lactide) (PDLLA) composite fibrous nonwoven mats for the first time to the best of our knowledge. The morphology of the fibers was observed by a scanning electron microscope (SEM) and transmission electron microscope (TEM). The secondary structure change of the spidroin before and after electrospinning was characterized using Fourier transform infrared spectroscopy (FT-IR). Herein, a qualitative analysis of the conformational changes of the silk protein was performed by analyzing the FT-IR second-derivative spectra, from which quantitative information was obtained via the deconvolution of the amide I band. A mechanical test was carried out to investigate the tensile strength and the elongation at break. A water contact angle (CA) measurement was also performed to characterize surface properties of the fibers. The cytotoxicity of electrospun PDLLA and Ss−PDLLA nonwoven fibrous mats was evaluated based on a CCL 81(Vero) cells proliferation study. The results showed that the hydrophilic and mechanical property of the composite fiber were improved by introducing spidroin.