Investigation of Drug Release and Matrix Degradation of Electrospun Poly(DL-lactide) Fibers with Paracetanol Inoculation
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- 作者：Wenguo Cui ; Xiaohong Li ; Xinli Zhu ; Guo Yu ; Shaobing Zhou ; and Jie Weng
- 刊名：Biomacromolecules
- 出版年：2006
- 出版时间：May 2006
- 年：2006
- 卷：7
- 期：5
- 页码：1623 - 1629
- 全文大小：288K
- 年卷期：v.7,no.5(May 2006)
- ISSN：1526-4602
文摘
This study was aimed at assessing the potential use of electrospun fibers as drug delivery vehicles with focus onthe different diameters and drug contents to control drug release and polymer fiber degradation. A drug-loadedsolvent-casting polymer film was made with an average thickness of 100 
m for comparative purposes. DSCanalysis indicated that electrospun fibers had a lower Tg but higher transition enthalpy than solvent-casting polymerfilm due to the inner stress and high degree of alignment and orientation of polymer chains caused by theelectrospinning process. Inoculation of paracetanol led to a further slight decrease in the Tg and transition enthalpy.An in vitro drug release study showed that a pronounced burst release or steady release phase was initially observedfollowed by a plateau or gradual release during the rest time. Fibers with a larger diameter exhibited a longerperiod of nearly zero order release, and higher drug encapsulation led to a more significant burst release afterincubation. In vitro degradation showed that the smaller diameter and higher drug entrapment led to more significantchanges of morphologies. The electrospun fiber mat showed almost no molecular weight reduction, but mass losswas observed for fibers with small and medium size, which was characterized with surface erosion and inconsistentwith the ordinarily polymer degrading form. Further wetting behavior analysis showed that the high water repellentproperty of electrospun fibers led to much slower water penetration into the fiber mat, which may contribute tothe degradation profiles of surface erosion. The specific degradation profile and adjustable drug release behaviorsby variation of fiber characteristics made the electrospun nonwoven mat a potential drug delivery system ratherthan polymer films and particles.
m for comparative purposes. DSCanalysis indicated that electrospun fibers had a lower Tg but higher transition enthalpy than solvent-casting polymerfilm due to the inner stress and high degree of alignment and orientation of polymer chains caused by theelectrospinning process. Inoculation of paracetanol led to a further slight decrease in the Tg and transition enthalpy.An in vitro drug release study showed that a pronounced burst release or steady release phase was initially observedfollowed by a plateau or gradual release during the rest time. Fibers with a larger diameter exhibited a longerperiod of nearly zero order release, and higher drug encapsulation led to a more significant burst release afterincubation. In vitro degradation showed that the smaller diameter and higher drug entrapment led to more significantchanges of morphologies. The electrospun fiber mat showed almost no molecular weight reduction, but mass losswas observed for fibers with small and medium size, which was characterized with surface erosion and inconsistentwith the ordinarily polymer degrading form. Further wetting behavior analysis showed that the high water repellentproperty of electrospun fibers led to much slower water penetration into the fiber mat, which may contribute tothe degradation profiles of surface erosion. The specific degradation profile and adjustable drug release behaviorsby variation of fiber characteristics made the electrospun nonwoven mat a potential drug delivery system ratherthan polymer films and particles.