Highly Enantioselective Synthesis of Tetrahydroquinolines via Cobalt(II)-Catalyzed Tandem 1,5-Hydride Transfer/Cyclization

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• 作者：Weidi Cao ; Xiaohua Liu ; Wentao Wang ; Lili Lin ; Xiaoming Feng
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：February 18, 2011
• 年：2011
• 卷：13
• 期：4
• 页码：600-603
• 全文大小：749K
• 年卷期：v.13,no.4(February 18, 2011)
• ISSN：1523-7052

文摘

A chiral catalyst prepared from N,N鈥?/i>-dioxide and Co(BF₄)₂路6H₂O was applied in the asymmetric hydride transfer initiated cyclization reaction, giving optically active tetrahydroquinolines in good yields with high enantioselectivities under mild reaction conditions. Meanwhile, in light of the absolute configuration of the product, a possible working model was proposed to explain the origin of the activation and asymmetric induction.