Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

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• 作者：Shogo Mori ; Keshav K. Nepal ; Gilbert T. Kelly ; Vasudha Sharma ; Dinesh Simkhada ; Vishruth Gowda ; Dioscar Delgado ; Coran M. H. Watanabe
• 刊名：Biochemistry
• 出版年：2017
• 出版时间：February 14, 2017
• 年：2017
• 卷：56
• 期：6
• 页码：805-808
• 全文大小：303K
• ISSN：1520-4995

文摘

The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.