Dimeric Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Anti-Hepatitis B Virus Activities
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- 作者：Yu-Bo Zhang ; Li-Qin Zhan ; Guo-Qiang Li ; Feng Wang ; Ying Wang ; Yao-Lan Li ; Wen-Cai Ye ; Guo-Cai Wang
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：August 5, 2016
- 年：2016
- 卷：81
- 期：15
- 页码：6273-6280
- 全文大小：463K
- 年卷期：0
- ISSN：1520-6904
文摘
Six unusual matrine-type alkaloid dimers, flavesines A–F (1–6, respectively), together with three proposed biosynthetic intermediates (7–9) were isolated from the roots of Sophora flavescens. Compounds 1–5 were the first natural matrine-type alkaloid dimers, and compound 6 represented an unprecedented dimerization pattern constructed by matrine and (−)-cytisine. Their structures were elucidated by NMR, MS, single-crystal X-ray diffraction, and a chemical method. The hypothetical biogenetic pathways of 1–6 were also proposed. Compounds 1–9 exhibited inhibitory activities against hepatitis B virus.