Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1

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• 作者：Yixi Liu ; Kelly Young ; L. Harinantenaina Rakotondraibe ; Peggy J. Brodie ; Jessica D. Wiley ; Maria B. Cassera ; Martin W. Callmander ; R. Rakotondrajaona ; Etienne Rakotobe ; Vincent E. Rasamison ; Karen TenDyke ; Yongchun Shen ; David G. I. Kingston
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：July 24, 2015
• 年：2015
• 卷：78
• 期：7
• 页码：1543-1547
• 全文大小：275K
• ISSN：1520-6025

文摘

The two new lignans 3伪-O-(尾-d-glucopyranosyl)desoxypodophyllotoxin (1) and 4-O-(尾-d-glucopyranosyl)dehydropodophyllotoxin (2) were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin (3), (卤)-尾-apopicropodophyllin (4), (鈭?-desoxypodophyllotoxin (5), (鈭?-yatein (6), and 尾-peltatin-5-O-尾-d-glucopyranoside (7). The structures of all compounds were characterized by spectroscopic techniques. Compounds 1, 4, and 5 showed potent antiproliferative activities against the A2780 ovarian cancer cell line, with IC₅₀ values of 33.0 卤 3.6, 63.1 卤 6.7, and 230 卤 1 nM, respectively. Compounds 2 and 7 showed only modest A2780 activities, with IC₅₀ values of 2.1 卤 0.3 and 4.9 卤 0.1 渭M, respectively, while compounds 3 and 6 had IC₅₀ values of >10 渭M. Compound 1 also had potent antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC₅₀ value of 20.5 nM, and compound 4 exhibited modest antiproliferative activity against the A2058 human caucasian metastatic melanoma and MES-SA human uterine sarcoma cell lines, with IC₅₀ values of 4.6 and 4.0 渭M, respectively.