DNA鈥揚rotein Cross-Links: Formation, Structural Identities, and Biological Outcomes

详细信息    查看全文

• 作者：Natalia Y. Tretyakova ; Arnold Groehler ; IV ; Shaofei Ji
• 刊名：Accounts of Chemical Research
• 出版年：2015
• 出版时间：June 16, 2015
• 年：2015
• 卷：48
• 期：6
• 页码：1631-1644
• 全文大小：976K
• ISSN：1520-4898

文摘

Noncovalent DNA鈥損rotein interactions are at the heart of normal cell function. In eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for chromosomal packaging in the nucleus. Binding of regulatory protein factors to DNA directs replication, controls transcription, and mediates cellular responses to DNA damage. Because of their fundamental significance in all cellular processes involving DNA, dynamic DNA鈥損rotein interactions are required for cell survival, and their disruption is likely to have serious biological consequences.