Oleanane-Type Triterpenoids from Aceriphyllum rossii and Their Cytotoxic Activity

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• 作者：Le Thi Kim Van ; Tran Manh Hung ; Phuong Thien Thuong ; Tran Minh Ngoc ; Jin Cheol Kim ; Han-Su Jang ; Xing Fu Cai ; Sei Ryang Oh ; Byung-Sun Min ; Mi Hee Woo ; Jae Sue Choi ; Hyeong Kyu Lee ; KiHwan Bea
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：August 28, 2009
• 年：2009
• 卷：72
• 期：8
• 页码：1419-1423
• 全文大小：107K
• 年卷期：v.72,no.8(August 28, 2009)
• ISSN：1520-6025

文摘

The hexane-soluble fraction of the roots of Aceriphyllum rossii was used to isolate seven new oleanane-type triterpenoids, aceriphyllic acids C−I (1−7), together with seven known triterpenoids. The structures of aceriphyllic acids C−I were determined as 3α-hydroxyolean-12-en-23,29-dioic acid (1), 3β-hydroxyolean-12-en-23,29-dioic acid (2), 3β,23-dihydroxyolean-12-en-29-oic acid (3), 3α-O-acetylolean-12-en-23,27-dioic acid (4), 3α-O-caffeoylolean-12-en-27-oic acid (5), 3α-O-acetylolean-12-en-23,29-dioic acid (6), and 3α-hydroxyolean-12-en-23-al-27-oic acid (7) by spectroscopic analyses. In the evaluation of the in vitro cytotoxicity of these compounds against the MCF-7 and LLC cancer cell lines, compounds 10 and 13 exhibited cytotoxic activity against the LLC cancer cell line with IC₅₀ values of 7.63 and 6.56 μM, respectively.