Penibruguieramine A, a Novel Pyrrolizidine Alkaloid from the Endophytic Fungus Penicillium sp. GD6 Associated with Chinese Mangrove Bruguiera gymnorrhiza

详细信息    查看全文

• 作者：Zhen-Fang Zhou ; Tibor Kurt谩n ; Xiao-Hong Yang ; Attila M谩ndi ; Mei-Yu Geng ; Bo-Ping Ye ; Orazio Taglialatela-Scafati ; Yue-Wei Guo
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1390-1393
• 全文大小：246K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

A novel pyrrolizidine alkaloid, penibruguieramine A (1), characterized by an unprecedented 1-alkenyl-2-methyl-8-hydroxymethylpyrrolizidin-3-one skeleton, was isolated from the endophytic fungus Penicillium sp. GD6, associated with the Chinese mangrove Bruguiera gymnorrhiza. The absolute configuration of penibruguieramine A (1) was established by TDDFT ECD calculations of the vacuum and solution conformers, exploiting the transitions of the lactam chromophore. A plausible pathway for its biosynthesis has been proposed.