Au-Modified Monolayer MoS2 Sensor for DNA Detection

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• 作者：Ke Jin ; Liming Xie ; Yu Tian ; Dameng Liu
• 刊名：Journal of Physical Chemistry C
• 出版年：2016
• 出版时间：May 26, 2016
• 年：2016
• 卷：120
• 期：20
• 页码：11204-11209
• 全文大小：481K
• 年卷期：0
• ISSN：1932-7455

文摘

Recently, molybdenum disulfide (MoS₂) has attracted considerable attention in the field of biomolecular detection owing to its large surface area and remarkable optoelectronic properties. Here, we report on a novel Au-modified monolayer MoS₂ sensor that allows rapid, sensitive, and selective detection of DNA molecules. The Au-thiol bond can effectively enhance the DNA adsorption on MoS₂. With the increasing concentration of DNA solution, the photoluminescence peak shows a prominent blueshift induced by the decrease of dielectric constant around MoS₂. The monolayer MoS₂ nanosheet exhibits different photoluminescence properties toward single-strained DNA versus double-strained DNA. Thus, the complementary target DNA could be distinguished from mismatched DNA through the photoluminescence spectra of MoS₂. The density functional theory calculation of MoS₂/DNA systems was performed to explore the detection mechanism. This work could promote the research of novel sensing platform by coupling nanomaterials with biomolecular recognition events.