Enantioselective Friedel-Crafts Reaction of Electron-Rich Alkenes Catalyzed by Chiral Brnsted Acid

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• 作者：Masahiro Terada ; Keiichi Sorimachi
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：January 17, 2007
• 年：2007
• 卷：129
• 期：2
• 页码：292 - 293
• 全文大小：60K
• 年卷期：v.129,no.2(January 17, 2007)
• ISSN：1520-5126

文摘

We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Brnsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel-Crafts products in high yield and enantioselectivity.