A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC

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• 作者：Derek A. Pflum ; H. Scott Wilkinson ; Gerald J. Tanoury ; Donald W. Kessler ; Hali B. Kraus ; Chris H. Senanayake ; and Stephen A. Wald
• 刊名：Organic Process Research & Development
• 出版年：2001
• 出版时间：March 2001
• 年：2001
• 卷：5
• 期：2
• 页码：110 - 115
• 全文大小：68K
• 年卷期：v.5,no.2(March 2001)
• ISSN：1520-586X

文摘

Enantiomerically pure cetirizine can be prepared by preparativeHPLC separation of cetirizine amide. The amide has an valueof 2.76 (USP resolution of 8.54) using a Chiralpak AD column,and 0.5 wt % of the amide (based on packing material) can beinjected per run.