Single-Nanoparticle Detection Using a Low-Aspect-Ratio Pore

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• 作者：Makusu Tsutsui ; Sadato Hongo ; Yuhui He ; Masateru Taniguchi ; Nobuhiro Gemma ; Tomoji Kawai
• 刊名：ACS Nano
• 出版年：2012
• 出版时间：April 24, 2012
• 年：2012
• 卷：6
• 期：4
• 页码：3499-3505
• 全文大小：434K
• 年卷期：v.6,no.4(April 24, 2012)
• ISSN：1936-086X

文摘

We explored single-particle translocation through a low thickness-to-diameter aspect ratio Si₃N₄ pore mimicking graphene nanopore structure by a resistive pulse method. Ionic conductance of 0.05 aspect ratio pores scales linearly with the diameter, indicating predominant contribution of the access resistance to the ion transport. We find that the access resistance changes little during particle translocation. Furthermore, we observe enhanced particle capture rates via the strong electric field extended outside the low-aspect-ratio pore mouth. We also demonstrate electrical discrimination of two different sized particles using the low-aspect-ratio pore sensor with the constant access resistance assumption. The present findings indicate the potential utility of nucleotide-sized graphene nanopores as an electrical sensing platform for single-base identification via transmembrane ionic current blockade detections.

Keywords:

solid-state nanopore; access resistance; low aspect ratio; ionic current blockage; single-particle detection