Uvaridacols E鈥揌, Highly Oxygenated Antiausterity Agents from Uvaria dac

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• 作者：Suresh Awale ; Jun-ya Ueda ; Sirivan Athikomkulchai ; Dya Fita Dibwe ; Sherif Abdelhamed ; Satoru Yokoyama ; Ikuo Saiki ; Ryuta Miyatake
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：November 26, 2012
• 年：2012
• 卷：75
• 期：11
• 页码：1999-2002
• 全文大小：279K
• 年卷期：v.75,no.11(November 26, 2012)
• ISSN：1520-6025

文摘

Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E鈥揌 (1鈥?b>4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.