Lipase-Catalyzed Biodegradation of Poly(-caprolactone) Blended with Various Polylactide-Based Polymers
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- 作者：Suming Li ; Lijian Liu ; Henri Garreau ; and Michel Vert
- 刊名：Biomacromolecules
- 出版年：2003
- 出版时间：March 2003
- 年：2003
- 卷：4
- 期：2
- 页码：372 - 377
- 全文大小：361K
- 年卷期：v.4,no.2(March 2003)
- ISSN：1526-4602
文摘
Poly(
-caprolactone) was blended with various polylactide-based polymers and processed to films by thesolution casting method. Blends of 25/75, 50/50, 75/25, 90/10, and 95/5 (w/w) poly(-caprolactone)/poly(L-lactide), a 95/5 (w/w) blend of poly(-caprolactone) with a poly(D-lactide), a 50/50 (w/w) poly(L-lactide)-poly(D-lactide) mixture, and a poly(L-lactide-co--caprolactone) copolymer were considered comparatively.The various phase-separated films were allowed to degrade in the presence of Pseudomonas lipase,biodegradation being monitored by proton nuclear magnetic resonance, size exclusion chromatography,differential scanning calorimetry, X-ray diffraction, and environmental scanning electron microscopy. Theformation of separated phases during solvent evaporation and their morphologies are discussed. Theintroduction of poly(L-lactide) dramatically decreased the degradation rate of poly(-caprolactone)/poly(L-lactide) blends. The higher the percentage of poly(L-lactide), the slower the degradation, while the presenceof cracks and increasing the lipase concentration acted in favor of the enzymatic degradation. Long-termenzymatic degradation of the various 95/5 blends was investigated over 480 h. The poly(-caprolactone)phase was enzymatically degraded by the lipase regardless of the blend type, the degradation rate dependingon the nature of the co-components.
-caprolactone) was blended with various polylactide-based polymers and processed to films by thesolution casting method. Blends of 25/75, 50/50, 75/25, 90/10, and 95/5 (w/w) poly(-caprolactone)/poly(L-lactide), a 95/5 (w/w) blend of poly(-caprolactone) with a poly(D-lactide), a 50/50 (w/w) poly(L-lactide)-poly(D-lactide) mixture, and a poly(L-lactide-co--caprolactone) copolymer were considered comparatively.The various phase-separated films were allowed to degrade in the presence of Pseudomonas lipase,biodegradation being monitored by proton nuclear magnetic resonance, size exclusion chromatography,differential scanning calorimetry, X-ray diffraction, and environmental scanning electron microscopy. Theformation of separated phases during solvent evaporation and their morphologies are discussed. Theintroduction of poly(L-lactide) dramatically decreased the degradation rate of poly(-caprolactone)/poly(L-lactide) blends. The higher the percentage of poly(L-lactide), the slower the degradation, while the presenceof cracks and increasing the lipase concentration acted in favor of the enzymatic degradation. Long-termenzymatic degradation of the various 95/5 blends was investigated over 480 h. The poly(-caprolactone)phase was enzymatically degraded by the lipase regardless of the blend type, the degradation rate dependingon the nature of the co-components.