Oxidative Amination of Cuprated Pyrimidine and Purine Derivatives
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- 作者：Nadè ; ge Boudet ; Srinivas Reddy Dubbaka ; Paul Knochel
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：May 1, 2008
- 年：2008
- 卷：10
- 期：9
- 页码：1715 - 1718
- 全文大小：123K
- 年卷期：v.10,no.9(May 1, 2008)
- ISSN：1523-7052
文摘
Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.