Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C-Glycosides
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- 作者：Baudouin Gerard ; Maurice D. Lee ; IV ; Sivaraman Dandapani ; Jeremy R. Duvall ; Mark E. Fitzgerald ; Sarathy Kesavan ; Jason T. Lowe ; Jean-Charles Mari茅 ; Bhaumik A. Pandya ; Byung-Chul Suh ; Morgan Welzel O鈥橲hea ; Michael Dombrowski ; Diane Hamann ; Berenice Lemercier ; Tiffanie Murillo ; Lakshmi B. Akella ; Michael A. Foley ; Lisa A. Marcaurelle
- 刊名：The Journal of Organic Chemistry
- 出版年：2013
- 出版时间：June 7, 2013
- 年：2013
- 卷：78
- 期：11
- 页码：5160-5171
- 全文大小：467K
- 年卷期：v.78,no.11(June 7, 2013)
- ISSN：1520-6904
文摘
A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) analysis.