Phloroglucinols with Antioxidant Activity and Xanthonolignoids from the Heartwood of Hypericum geminiflorum
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- 作者：Chien-Chang Wu ; Ming-Hong Yen ; Shyh-Chyun Yang ; Chun-Nan Lin
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：71
- 期：6
- 页码：1027 - 1031
- 全文大小：114K
- 年卷期：v.71,no.6(June 2008)
- ISSN：1520-6025
文摘
A new phloroglucinol, hyperielliptone HA (1/1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB (2/2a), and two new xanthonolignoids, hyperielliptones HC (3) and HD (4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/1a and 2/2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase.