PhI(OCOCF3)2-Mediated Intramolecular Oxidative N鈥揘 Bond Formation: Metal-Free Synthesis of 1,2,4-Triazolo[1,5-a]pyridines
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- 作者：Zisheng Zheng ; Shuangyu Ma ; Linlin Tang ; Daisy Zhang-Negrerie ; Yunfei Du ; Kang Zhao
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：May 16, 2014
- 年：2014
- 卷：79
- 期：10
- 页码：4687-4693
- 全文大小：394K
- 年卷期：v.79,no.10(May 16, 2014)
- ISSN：1520-6904
文摘
The biologically important 1,2,4-triazolo[1,5-a]pyridines were readily synthesized from N-(pyridin-2-yl)benzimidamides via phenyliodine bis(trifluoroacetate)-mediated intramolecular annulation. This novel strategy allows for the convenient construction of a 1,2,4-triazolo[1,5-a]pyridine skeleton through direct metal-free oxidative N鈥揘 bond formation, featuring a short reaction time and high reaction yields.