Direct Oxidation of Aliphatic C–H Bonds in Amino-Containing Molecules under Transition-Metal-Free Conditions
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- 作者：Xin Li ; Xing Che ; Gui-Hua Chen ; Jun Zhang ; Jia-Lei Yan ; Yun-Fei Zhang ; Li-Sheng Zhang ; Chao-Ping Hsu ; Yi Qin Gao ; Zhang-Jie Shi
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：March 18, 2016
- 年：2016
- 卷：18
- 期：6
- 页码：1234-1237
- 全文大小：430K
- ISSN：1523-7052
文摘
By employing a simple, inexpensive, and transition-metal-free oxidation system, secondary C–H bonds in a series of phthaloyl protected primary amines and amino acid derivatives were oxidized to carbonyls with good regioselectivities. This method could also be applied to oxidize tertiary C–H bonds and modify synthetic dipeptides.