New Inhibitors of ROS Generation and T-Cell Proliferation from Myrtus communis

详细信息    查看全文

• 作者：M. Iqbal Choudhary ; Noureen Khan ; Manzoor Ahmad ; Sammer Yousuf ; Hoong-Kun Fun ; Samreen Soomro ; M. Asif ; M. Ahmed Mesaik ; Farzana Shaheen
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 19, 2013
• 年：2013
• 卷：15
• 期：8
• 页码：1862-1865
• 全文大小：254K
• 年卷期：v.15,no.8(April 19, 2013)
• ISSN：1523-7052

文摘

Phytochemical investigation on Myrtus communis Linn. afforded myrtucommuacetalone (1) with an unprecedented carbon skeleton and a new phloroglucinol-type compound, myrtucommulone M (2), along with four known constituents 3鈥?b>6. Their structures were established by extensive analyses of NMR and mass spectral data as well as by single-crystal X-ray diffraction studies. These constituents were evaluated for their ability to modulate the immune response, based on their effects on various components of immune system. Compounds 1 and 5 exhibited significant inhibitory effect against nitric oxide (NO^{鈥?/sup>) production. Compound 1 also exhibited significant antiproliferative activity (IC₅₀ < 0.5 渭g/mL) against T-cell proliferation. Myricetin (3) exerted a significant inhibition (IC₅₀ = 1.6 渭g/mL) on zymosan-stimulated whole blood phagocytes ROS production. Compounds 1 and 3 were active against PMA-stimulated ROS generation.}