Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes

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• 作者：Satoshi Mizuta ; Ida S. R. Stenhagen ; Miriam O鈥橠uill ; Jamie Wolstenhulme ; Anna K. Kirjavainen ; Sarita J. Forsback ; Matthew Tredwell ; Graham Sandford ; Peter R. Moore ; Mickael Huiban ; Sajinder K. Luthra ; Jan Passchier ; Olof Solin ; V茅ronique Gouverneur
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 7, 2013
• 年：2013
• 卷：15
• 期：11
• 页码：2648-2651
• 全文大小：284K
• 年卷期：v.15,no.11(June 7, 2013)
• ISSN：1523-7052

文摘

Treatment of readily available 伪,伪-difluoro- and 伪-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [¹⁸F]labeling is demonstrated using [¹⁸F]Selectfluor bis(triflate), a reagent affording [¹⁸F]tri- and [¹⁸F]difluoromethylarenes not within reach with [¹⁸F]F₂.