Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3-Mediated Reductive Cyclopropanation
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- 作者：Rong Zhou ; Changjiang Yang ; Yiyi Liu ; Ruifeng Li ; Zhengjie He
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：November 7, 2014
- 年：2014
- 卷：79
- 期：21
- 页码：10709-10715
- 全文大小：368K
- ISSN：1520-6904
文摘
A P(NMe2)3-mediated reductive cyclopropanation reaction of 伪-keto esters or amides with isatin-derived alkenes has been developed, providing efficient and diastereoselective synthesis of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon quaternary centers. This reaction also represents a complementary and nonmetal-involving protocol for the challenging cyclopropanation of electron-deficient alkenes.