Wang Linker Free of Side Reactions

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• 作者：Vida Castro ; Hortensia Rodriguez ; Fernando Albericio
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：15
• 期：2
• 页码：246-249
• 全文大小：250K
• 年卷期：v.15,no.2(January 18, 2013)
• ISSN：1523-7052

文摘

A new resin for the solid-phase synthesis of peptide acids was developed. It was based on a linker with two unique features: methoxy groups as the only activating groups of the phenyl ring and a copper(I)-catalyzed Click chemistry reaction to anchor it to the solid support. The efficiency of this new resin in solid phase peptide synthesis was compared with that of Wang resin.