Synthesis and Characterization of Thermosensitive PNIPAM Microgels Covered with Superparamagnetic -Fe2O3 Nanoparticles

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• 作者：Jorge Rubio-Retama ; Nikolaos E. Zafeiropoulos ; Caterina Serafinelli ; Rosana Rojas-Reyna ; Brigitte Voit ; E. Lopez Cabarcos ; Manfred Stamm
• 刊名：Langmuir
• 出版年：2007
• 出版时间：September 25, 2007
• 年：2007
• 卷：23
• 期：20
• 页码：10280 - 10285
• 全文大小：513K
• 年卷期：v.23,no.20(September 25, 2007)
• ISSN：1520-5827

文摘

In the present study we report a facile and reproducible method of preparing magnetic thermosensitive hybridmaterial based on P(NIPAM) microgels covered with -Fe₂O₃ nanoparticles of 6-nm size. The iron oxide nanoparticlesprovided magnetic response to the microgels. In addition, the presence of the magnetic nanoparticles on the microgelsaltered their swelling behavior and shifted their volume phase transition temperature to higher values. In particular,for inorganic shells with 18% (w/w) of magnetic nanoparticles the volume phase transition of the microgels was shiftedfrom 36 to 40 C. In contrast, for shells consisting of 38% (w/w) magnetic nanoparticles the volume phase transitionof the microgels was almost blocked, thus indicating that the microgel thermal response was strongly affected by thepresence of the inorganic nanoparticles. The synthesized thermosensitive magnetic microgels are envisaged to be idealfor potential applications as thermosensitive targeted drug delivery systems.