Elemental Tomography of Cancer-Cell Spheroids Reveals Incomplete Uptake of Both Platinum(II) and Platinum(IV) Complexes
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- 作者：Rebecca A. Alderden ; Howard R. Mellor ; Szabolcs Modok ; Matthew D. Hall ; Stephen R. Sutton ; Matthew G. Newville ; Richard Callaghan ; Trevor W. Hambley
- 刊名：Journal of the American Chemical Society
- 出版年：2007
- 出版时间：November 7, 2007
- 年：2007
- 卷：129
- 期：44
- 页码：13400 - 13401
- 全文大小：181K
- 年卷期：v.129,no.44(November 7, 2007)
- ISSN：1520-5126
文摘
The limited penetration of cytotoxic drugs into tumors is a significant contributing factor to the limited effectiveness of cancer chemotherapy. Here we have shown that X-ray fluorescence microtomography is a suitable technique for imaging the distribution of Pt drugs within multicellular tumor spheroids, models of solid tumors. This has revealed that there is no significant difference between the distributions of the range of Pt(II) and Pt(IV) complexes investigated, suggesting that complexes that are more resistant to cellular uptake may be needed to ensure more complete distribution throughout a tumor.