Carboxamide versus Sulfonamide in Peptide Backbone Folding: A Case Study with a Hetero Foldamer

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• 作者：Veera V. E. Ramesh ; Sangram S. Kale ; Amol S. Kotmale ; Rupesh L. Gawade ; Vedavati G. Puranik ; P. R. Rajamohanan ; Gangadhar J. Sanjayan
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：15
• 期：7
• 页码：1504-1507
• 全文大小：278K
• 年卷期：v.15,no.7(April 5, 2013)
• ISSN：1523-7052

文摘

Strikingly dissimilar hydrogen-bonding patterns have been observed for two sets of closely similar hetero foldamers containing carboxamide and sulfonamides at regular intervals. Although both foldamers maintain conformational ordering, the hydrogen-bonding pattern and backbone helical handedness differ diametrically.