I2-Catalyzed Oxidative Cross-Coupling of Methyl Ketones and Benzamidines Hydrochloride: A Facile Access to 伪-Ketoimides

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• 作者：Xia Wu ; Qinghe Gao ; Shan Liu ; Anxin Wu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：16
• 期：11
• 页码：2888-2891
• 全文大小：329K
• 年卷期：v.16,no.11(June 6, 2014)
• ISSN：1523-7052

文摘

An iodine-catalyzed oxidative cross-coupling of C鈥揌/N鈥揌 has been demonstrated. This simple and efficient approach constructed 伪-ketoimides in good to excellent yields from methyl ketones and benzamidines hydrochloride under metal-free and peroxide-free conditions. This synthetic strategy was achieved via an in situ iodination-based oxidative coupling pathway.