Synthesis of Indeno[1,2-c]furans via a Pd-Catalyzed Bicyclization of 2-Alkynyliodobenzene and Propargylic Alcohol
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- 作者：Jisong Jin ; Yan Luo ; Chao Zhou ; Xiaopeng Chen ; Qiaodong Wen ; Ping Lu ; Yanguang Wang
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：December 21, 2012
- 年：2012
- 卷：77
- 期：24
- 页码：11368-11371
- 全文大小：223K
- 年卷期：v.77,no.24(December 21, 2012)
- ISSN：1520-6904
文摘
A general and efficient synthesis of indeno[1,2]furans via a Pd-catalyzed bicyclization reaction between 2-alkynyliodobenzenes and propargylic alcohols is described. The procedure furnishes indeno[1,2]furans with moderate to excellent yields (51%鈥?8%) and a broad substrate scope. The cascade process combines the formation of one C鈥揙 bond and two C鈥揅 bonds in a single step.