Development of U11-Functionalized Gold Nanoparticles for Selective Targeting of Urokinase Plasminogen Activator Receptor-Positive Breast Cancer Cells

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• 作者：Svetlana Avvakumova ; Elisabetta Galbiati ; Laura Pandolfi ; Serena Mazzucchelli ; Marco Cassani ; Alessandro Gori ; Renato Longhi ; Davide Prosperi
• 刊名：Bioconjugate Chemistry
• 出版年：2014
• 出版时间：August 20, 2014
• 年：2014
• 卷：25
• 期：8
• 页码：1381-1386
• 全文大小：332K
• ISSN：1520-4812

文摘

The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells.