Nitrogen Oxide Inhibitory Trimeric and Dimeric Carbazole Alkaloids from Murraya tetramera

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• 作者：Hai-Ning Lv ; Ran Wen ; Ying Zhou ; Ke-Wu Zeng ; Jun Li ; Xiao-Yu Guo ; Peng-Fei Tu ; Yong Jiang
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2432-2439
• 全文大小：313K
• ISSN：1520-6025

文摘

Two new structurally unique trimeric carbazole alkaloids, murratrines A and B (1, 2), and 11 new carbazole dimers, murradines A鈥揔 (3鈥?b>13), and four known analogues (14鈥?b>17) were isolated from the leaves and stems of Murraya tetramera. The structures and relative configurations of 1鈥?b>13 were elucidated on the basis of comprehensive 1D and 2D NMR spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism (ECD) data analysis. Murratrines A and B (1, 2) both contain an unprecedented carbazole trimeric skeleton, and murradines A and D (3, 6) are the first natural C-1鈥揅-3鈥?methyl-linked and C-6鈥揅-3鈥?methyl-linked dimeric carbazole alkaloids, respectively. Compounds 4, 10, 14, 15, and 17 exhibited inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC₅₀ values in the range of 11.2鈥?9.3 渭M.