Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium
详细信息 查看全文
- 作者：Hidetoshi Ogawa ; Arihiro Iwasaki ; Shimpei Sumimoto ; Masato Iwatsuki ; Aki Ishiyama ; Rei Hokari ; Kazuhiko Otoguro ; Satoshi O̅mura ; Kiyotake Suenaga
- 刊名：Organic Letters
- 出版年：2017
- 出版时间：February 17, 2017
- 年：2017
- 卷：19
- 期：4
- 页码：890-893
- 全文大小：300K
- ISSN：1523-7052
文摘
In the search for new antiprotozoal substances, hoshinolactam, an antitrypanosomal lactam, was isolated from a marine cyanobacterium. The gross structure was elucidated by spectroscopic analyses, and the absolute configuration was determined by the first total synthesis. Hoshinolactam showed potent antitrypanosomal activity with an IC<sub>50sub> value of 3.9 nM without cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC<sub>50sub> > 25 μM).