Cryogenic Process to Elaborate Poly(ethylene glycol) Scaffolds. Experimental and Simulation Studies

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• 作者：Ira铆s A. Quintero Ortega ; Josu茅 D. Mota-Morales ; Eduardo A. Elizalde Pe帽a ; Diana G. Z谩rate-Trivi帽o ; Yair A. De Santiago ; Arturo Ortiz ; Beatriz Garc铆a Gaitan ; Isaac C. Sanchez ; Gabriel Luna-B谩rcenas
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2013
• 出版时间：January 16, 2013
• 年：2013
• 卷：52
• 期：2
• 页码：706-715
• 全文大小：527K
• 年卷期：v.52,no.2(January 16, 2013)
• ISSN：1520-5045

文摘

Porous materials are of great importance because of their multiple applications in pharmacy, catalysis, and biomedicine among others. Ice segregation induced self-assembly (ISISA) is a cryogenic technique that uses the ice as a template that forms upon immersion of a polymer solution into liquid nitrogen to obtain highly porous materials. Some highlights of this technique are its versatility, simplicity, and control over the final structure of the produced material; besides, no organic solvents are used during the process, and the material can be used without the need of further cleaning. In this contribution, the elaboration of scaffolds using a poly(ethylene glycol) aqueous solutions by an ice-template process has been studied from experimental and theoretical viewpoints. The experimental study of the process parameters, such as immersion velocity and a prescribed freezing front on the morphology, was carried out. Simulations were performed to understand the ISISA process by calculating temperature profiles and pore size as a function of time. The most important result of this study was the effect of freezing rate on pore size. The technique was optimized such that a recipe is proposed to form materials with 1鈥?00 渭m pore sizes.