Caffeoylquinic Acid-Rich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8 Mouse
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- 作者：Kazunori Sasaki ; Junkyu Han ; Hidetoshi Shimozono ; Myra O. Villareal ; Hiroko Isoda
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2013
- 出版时间：May 29, 2013
- 年：2013
- 卷：61
- 期：21
- 页码：5037-5045
- 全文大小：321K
- 年卷期：v.61,no.21(May 29, 2013)
- ISSN：1520-5118
文摘
The effects of caffeoylquinic acid (CQA)-rich purple sweet potato (PSP) extract, with (PSPEa) or without (PSPEb) anthocyanin, on the improvement of spatial learning and memory of senescence-accelerated prone mouse strain (SAMP) 8 was determined. SAMP8 was treated with 20 mg/kg/day of PSPEa or PSPEb for 30 days. The effect on spatial learning and memory and the molecular mechanism of this effect were determined in vivo (SAMP8) and in vitro (SH-SY5Y cells). PSPEa or PSPEb reduced the escape latency time of SAMP8 by 17.0 卤 8.0 and 14.2 卤 5.8 s (P < 0.01), respectively. PSPEa administration induced an overexpression of antioxidant-, energy metabolism-, and neuronal plasticity-related proteins in the brain of SAMP8. Additionally, PSPEa and PSPEb increased the cell viability by 141.6 and 133% as compared to A尾1鈥?2-treated cells. These findings suggest that PSP rich in CQA derivatives with or without anthocyanidine had a neuroprotective effect on mouse brain and can improve the spatial learning and memory of SAMP8.