A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth
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- 作者：Constanze Lamprecht ; Mohammadreza Taale ; Ingo Paulowicz ; Hannes Westerhaus ; Carsten Grabosch ; Arnim Schuchardt ; Matthias Mecklenburg ; Martina Böttner ; Ralph Lucius ; Karl Schulte ; Rainer Adelung ; Christine Selhuber-Unkel
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2016
- 出版时间：June 22, 2016
- 年：2016
- 卷：8
- 期：24
- 页码：14980-14985
- 全文大小：470K
- 年卷期：0
- ISSN：1944-8252
文摘
Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days.